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NMN<\/strong><\/a>\u7684<\/strong>\u539f\u6599\u751f\u4ea7\u5de5\u827a<\/strong><\/h2>\n\n\n\n

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1. \u5316\u5b66\u5408\u6210\u6cd5<\/strong><\/h3>\n\n\n\n

<\/a>NMN<\/strong><\/a>\u7684\u5316\u5b66\u5408\u6210\u6cd5\uff0c\u8d77\u59cb\u8f83\u65e9\uff0c\u76ee\u524d\u6709\u591a\u79cd\u5408\u6210NMN<\/strong><\/a>\u5316\u5b66\u5408\u6210\u65b9\u6cd5\u5f97\u5230\u4e13\u5229\u6388\u6743\u3002\u4f46\u5316\u5b66\u5408\u6210\uff0c\u5982\u4f55\u9ad8\u9009\u62e9\u6027\u8fdb\u884c\u78f7\u9178\u5316\u4ee5\u53ca\u9ad8\u7acb\u4f53\u9009\u62e9\u6027\u6784\u5efabeta-NMN<\/strong><\/a>\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u6311\u6218\u6027\u3002\u540c\u65f6\uff0c\u6709\u4e9b\u5316\u5b66\u5408\u6210\u8def\u7ebf\u5728\u5408\u6210\u8fc7\u7a0b\u4e2d\u8981\u8fdb\u884c\u5404\u79cd\u6709\u673a\u5b98\u80fd\u56e2\u7684\u4fdd\u62a4\u548c\u53bb\u4fdd\u62a4\uff0c\u6216\u8005\u9700\u8981\u7528\u5230\u591a\u79cd\u6709\u673a\u6eb6\u5242, \u4f7f\u5f97NMN<\/strong><\/a>\u7684\u5408\u6210\u6210\u672c\u8f83\u5927\u3002\u65e0\u8bba\u662f\u5316\u5b66\u65b9\u6cd5\u6216\u8005\u540e\u9762\u63d0\u53ca\u7684\u5fae\u751f\u7269\u53d1\u9175\u3001\u9176\u6cd5\u5408\u6210\uff0c\u5bf9\u6700\u7ec8\u4ea7\u54c1\u7684\u6742\u8d28\u63a7\u5236\u662f\u4ea7\u54c1\u8d28\u91cf\u7684\u6838\u5fc3\u3002(Jaemoon Lee, et al. A chemical synthesis of nicotinamide adenine dinucleotide (NAD+). Chem. Commun.<\/em> 1999<\/strong>, 8, 729. https:\/\/doi-org.udel.idm.oclc.org\/10.1039\/A809930H<\/strong><\/a>)<\/p>\n\n\n\n

2. \u5fae\u751f\u7269\u53d1\u9175\u6cd5<\/strong><\/h3>\n\n\n\n

\u501f\u52a9\u5fae\u751f\u7269\u4ee5\u7c7b\u4f3c\u4e8e\u917f\u9152\u7684\u65b9\u5f0f\u8fdb\u884c\u751f\u4ea7NMN<\/a>\uff0c\u4e00\u822c\u6765\u8bb2\uff0c\u6240\u9700\u539f\u6599\u6210\u672c\u9ad8\u6602\uff0c\u751f\u4ea7\u6548\u7387\u6bd4\u8f83\u4f4e\uff0c\u4e0d\u5229\u4e8e\u5de5\u4e1a\u89c4\u6a21\u5316\u751f\u4ea7 (Kazane Sugiyama, et al. Nicotinamide mononucleotide production by fructophilic lactic acid bacteria. Scientific Reports<\/em>, 2021<\/strong>, 11, 7761. https:\/\/doi.org\/10.1038\/s41598-021-87361-1<\/a>) \u3002<\/p>\n\n\n\n

3. \u9176\u50ac\u5316\u5408\u6210\u6cd5<\/strong><\/h3>\n\n\n\n

NMN<\/a>\u7684\u751f\u7269\u9176\u50ac\u5316\u6cd5\uff0c\u662f\u6307\u4e0d\u501f\u52a9\u5fae\u751f\u7269\uff0c\u800c\u662f\u901a\u8fc7\u7279\u5b9a\u7684\u5de5\u7a0b\u9176\uff0c\u4ee5\u751f\u7269\u5408\u6210\u7684\u65b9\u5f0f\u6765\u8fdb\u884c\u751f\u4ea7\u3002\u6b64\u6cd5\u4e0d\u4ec5\u751f\u4ea7\u65b9\u5f0f\u76f8\u5bf9\u6e29\u548c\uff0c\u4ea7\u51fa\u7684NMN<\/a>\u539f\u6599\u7eaf\u5ea6\u9ad8\u4e14\u4e0d\u542b\u5916\u6e90\u6027\u6742\u8d28\uff0c\u751f\u7269\u6d3b\u6027\u4e5f\u8f83\u9ad8 (R. Jeck, et al. Simple methods of preparing nicotinamide mononucleotide, FEBS Lett.<\/em> 1974<\/strong>, 42, 161) \u3002\u5728\u6b64\u6cd5\u57fa\u7840\u4e0a\uff0c\u79d1\u5b66\u5bb6\u53c8\u5e94\u7528\u4e86\u9176\u5de5\u7a0b\u5b9a\u5411\u8fdb\u5316\u6280\u672f\uff0c\u6781\u5927\u5730\u63d0\u5347\u4e86\u751f\u4ea7\u6548\u7387\u4e0e\u4ea7\u54c1\u54c1\u8d28 (Qi Shen, et al. Biological synthesis of nicotinamide mononucleotide, Botechnol. Lett.<\/em> 2021, 43, 2199. https:\/\/doi.org\/10.1007\/s10529-021-03191-1<\/a>) \u3002<\/p>\n\n\n\n

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\u7279\u522b\u662f2022\u5e74\u6700\u65b0\u62a5\u9053\u7684\u4ee5\u70df\u9170\u80fa\u6838\u82f7\u9178\u4e3a\u539f\u6599\uff0c\u5229\u7528\u70df\u9170\u80fa\u6838\u82f7\u6fc0\u9176\u4e3a\u50ac\u5316\u5242\uff0c\u901a\u8fc7ATP\u518d\u751f\u8fc7\u7a0b\uff0c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5c06NMN<\/a>\u7684\u751f\u4ea7\u6548\u7387\u63d0\u9ad8\u5230\u6bcf\u5929281 g\/L\uff0c\u4ea7\u7387\u4e5f\u53ef\u4ee5\u8fbe\u523084.2%(X. Qian, et al. Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system. Bioresources and Bioprocessing, 2022, 9, 26. https:\/\/doi.org\/10.1186\/s40643-022-00514-6<\/a>)\u3002<\/p>\n\n\n\n

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Ay Health NMN27000<\/a><\/strong><\/figcaption><\/figure>\n\n\n\n

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