{"id":1985,"date":"2022-11-05T05:40:00","date_gmt":"2022-11-04T21:40:00","guid":{"rendered":"https:\/\/nmnsupply.com\/?p=1985"},"modified":"2022-11-06T23:11:27","modified_gmt":"2022-11-06T15:11:27","slug":"%e5%b8%82%e5%9c%ba","status":"publish","type":"post","link":"https:\/\/nmnsupply.com\/%e5%b8%82%e5%9c%ba","title":{"rendered":"\u6297\u8870\u8001\u795e\u5668NMN\u5e02\u573a\u4e3a\u4f55\u5982\u6b64\u4e4b\u706b\uff1f"},"content":{"rendered":"\n

\u8981\u70b9\uff1a<\/strong><\/strong><\/h2>\n\n\n\n
    \n
  1. \u5173\u952e\u4eba\u7269\uff1a\u54c8\u4f5b\u5927\u5b66David A. Sinclair\u6559\u6388\uff1b<\/li>\n\n\n\n
  2. \u5927\u91cf\u8d44\u672c\u5165\u573a\u63a8\u52a8\u6574\u4e2aNMN<\/strong><\/a>\u4ea7\u4e1a\u8fc5\u901f\u53d1\u5c55\uff1b<\/li>\n\n\n\n
  3. \u7c7b\u4f3c\u201c\u4e0d\u8001\u4ed9\u4e39\u201d\u7684\u529f\u6548\u8fc5\u901f\u63d0\u5347NMN<\/strong><\/a>\u7684\u5e02\u573a\u77e5\u540d\u5ea6\u3002<\/li>\n<\/ol>\n\n\n\n

    1. NMN<\/a>\u5173\u952e\u4eba\u7269\uff1a\u54c8\u4f5b\u5927\u5b66David A. Sinclair\u6559\u6388<\/strong> <\/h2>\n\n\n\n

    \u6291\u5236\u8870\u8001\u3001\u5ef6\u957f\u5bff\u547d\u5df2\u7ecf\u6210\u4e3a\u4e86\u4e0b\u4e00\u4e2a\u6295\u8d44\u7684\u98ce\u53e3\u3002\u534e\u5c14\u8857\u4e09\u5927\u6295\u884c\u4e4b\u4e00\u7f8e\u6797\u7684\u62a5\u544a\u4e2d\u663e\u793a\uff0c\u8be5\u5e02\u573a\u7684\u89c4\u6a21\u5df2\u7ecf\u8fbe\u5230<\/strong>1100\u4ebf\u7f8e\u5143\uff0c\u52302025\u5e74\uff0c\u5176\u89c4\u6a21\u66f4\u5c06\u8fbe\u52306000\u4ebf\u7f8e\u5143\u4ee5\u4e0a\u3002<\/strong><\/p>\n\n\n\n

    NMN<\/strong><\/a>\uff08\u03b2-\u70df\u9170\u80fa\u5355\u6838\u82f7\u9178\uff09\u4f5c\u4e3a\u4eba\u4f53\u4e2d\u4e00\u79cd\u5185\u6e90\u6027\u7269\u8d28\uff0c\u5728\u8bb8\u591a\u852c\u83dc\u4e0e\u6c34\u679c\u5f53\u4e2d\u4e5f\u5fae\u91cf\u5b58\u5728\u3002\u90a3\uff0cNMN<\/strong><\/a>\u4e3a\u4ec0\u4e48\u7a81\u7136\u5982\u6b64\u4e4b\u706b\u5462\uff1f\u8fd9\u4e3b\u8981\u5f52\u529f\u4e8e\u4ece\u4e8bNMN<\/strong><\/a>\u7814\u7a76\u7684\u5173\u952e\u4eba\u7269\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662David A. Sinclair\u6559\u6388\u3002<\/p>\n\n\n\n

    \"\u54c8\u4f5b\u5927\u5b66Sinclair\u6559\u6388\u7684NMN\u6297\u8870\u8001\u7814\u7a76\u662fNMN\u5e02\u573a\u706b\u7206\u7684\u57fa\u7840\"
    (https:\/\/sinclair.hms.harvard.edu<\/a>)<\/figcaption><\/figure>\n\n\n\n

    Sinclair\u6559\u6388\u548c\u4ed6\u7684\u56e2\u961f\u4e8e2013\u5e74\u4ee5\u6765\u5728\u591a\u79cd\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4e00\u7cfb\u5217\u6709\u5173NMN<\/strong><\/a>\u7684\u6587\u7ae0[1-8]\uff0c\u7ed3\u679c\u663e\u793a\u670d\u7528NMN<\/strong><\/a>\u540e\uff0c\u7ebf\u7c92\u4f53\u7a33\u6001\u3001\u808c\u8089\u5065\u5eb7\u7b49\u5173\u952e\u6307\u6807\u4e0a\u6709\u7740\u663e\u8457\u7684\u6539\u5584\uff0c\u5e76\u9996\u6b21\u8bc1\u660eNMN<\/strong><\/a>\u53ef\u4ee5\u6709\u6548\u5ef6\u7f13\u4e43\u81f3\u9006\u8f6c\u8870\u8001\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u9707\u60ca\u4e1a\u754c\u7684\u540c\u65f6\uff0c\u4e5f\u6fc0\u53d1\u4e86\u4e16\u754c\u5404\u56fd\u7814\u7a76\u8005\u5bf9NMN<\/strong><\/a>\u5404\u79cd\u529f\u6548\u7684\u63a2\u7d22\u5174\u8da3\u3002<\/p>\n\n\n\n

    \u66f4\u4e3a\u91cd\u8981\u7684\u662f\uff0c\u518d\u52a0\u4e0aDavid A. Sinclair\u6559\u6388\u4eb2\u81ea\u670d\u7528NMN<\/strong><\/a>\u591a\u5e74\uff0c\u5e76\u5ba3\u79f0\uff0c\u81ea\u5df1\u8fd160\u5c81\u7684\u5e74\u9f84\uff0c\u901a\u8fc7\u8840\u6db2\u5316\u9a8c\u53d1\u73b0\u81ea\u5df1\u7684\u751f\u7406\u5e74\u9f84\u7adf\u7136\u4e0e20\u591a\u5c81\u7684\u5e74\u8f7b\u4eba\u65e0\u5f02\u3002NMN<\/strong><\/a>\u4ea7\u54c1\u81ea\u6b64\u62e5\u6709\u4e86\u8bb8\u591a\u5fe0\u5b9e\u62e5\u8db8\u3002\u4e0d\u8fc7\u5f53\u65f6\u56e0\u4e3a\u53d7\u9650\u4e8eNMN<\/strong><\/a>\u83b7\u53d6\u6e20\u9053\u548c\u6210\u672c\uff0c\u4ec5\u6709\u4e00\u5c0f\u90e8\u5206\u7814\u7a76\u4eba\u5458\u548c\u5bcc\u7532\u5546\u8d3e\u4eec\u80fd\u591f\u6709\u80fd\u529b\u670d\u7528\u8fd9\u79cd\u7269\u8d28\u3002<\/p>\n\n\n\n

    \"\u8d8a\u8001\u8d8a\u591a\u7684\u4eba\u52a0\u5165\u63a8\u52a8\u4e86NMN\u4ea7\u54c1\u7684\u5e02\u573a\u5316\"<\/figure>\n\n\n\n

    \u5728\u4e2d\u56fd\uff0c\u6709\u9999\u6e2f\u7684\u4e0d\u8001\u8d85\u4eba\u674e\u9996\u5bcc\u4ee5\u53ca\u5185\u5730\u5730\u4ea7\u6f58\u5927\u5496\u662fNMN<\/strong><\/a>\u9996\u6279\u201c\u5c1d\u9c9c\u8005\u201d\u3002NMN<\/strong><\/a>\u6982\u5ff5\u4e0d\u4f46\u53d8\u5f97\u8d8a\u6765\u8d8a\u706b\u70ed\uff0c\u800c\u4e14\u56fd\u5185\u5e02\u573a\u4e5f\u5f00\u59cb\u8fce\u6765\u751f\u673a\u3002\u636e\u4e2d\u4fe1\u8bc1\u5238\u7814\u7a76\uff0cNMN<\/strong><\/a>\u5728\u4e2d\u56fd\u6709\u671b\u5f88\u5feb\u8fbe\u5230\u5343\u4ebf\u5e02\u573a\u89c4\u6a21\u3002<\/p>\n\n\n\n

    <\/p>\n\n\n\n

    2. \u5927\u91cf\u8d44\u672c\u5165\u573a\u63a8\u52a8\u6574\u4e2a<\/strong>NMN<\/a><\/strong>\u4ea7\u4e1a\u8fc5\u901f\u53d1\u5c55<\/strong><\/h2>\n\n\n\n

    \u8fd1\u51e0\u5e74\u6765\uff0c\u968f\u7740\u5bf9NMN\u8fd9\u79cd\u7269\u8d28\u7684\u7814\u7a76\u6108\u53d1\u6df1\u5165\uff0cNMN<\/strong><\/a>\u8d8a\u6765\u8d8a\u591a\u7684\u529f\u6548\u88ab\u63ed\u793a\u51fa\u6765\uff0c\u5982\u6539\u5584\u808c\u8089\u8870\u8001\u3001\u9006\u8f6c\u9020\u8840\u5e72\u7ec6\u80de\u6d3b\u6027\u3001\u7ef4\u6301\u7aef\u7c92\u957f\u5ea6\u7b49\u7b49\u3002\u4e3a\u4e86\u62a2\u5360\u672a\u6765\u66f4\u591a\u7684NMN<\/strong><\/a>\u5e02\u573a\u4efd\u989d\uff0c\u8bb8\u591a\u516c\u53f8\u65e9\u65e9\u5c31\u8fdb\u5165NMN<\/strong><\/a>\u9886\u57df\uff0c\u5e76\u4e14\u56e0\u4e3aNMN<\/strong><\/a>\u7684\u6982\u5ff5\u80a1\u4ef7\u5728\u77ed\u671f\u5185\u5927\u6da8\uff0c \u6bd4\u5982\u91d1\u8fbe\u5a01\u3001\u96c5\u672c\u5316\u5b66 \u3001\u7cbe\u5de5\u94a2\u6784\u3001\u5c14\u5eb7\u5236\u836f\u3001\u94f6\u79a7\u79d1\u6280\u7b49\u3002<\/p>\n\n\n\n

    \"\u5927\u91cf\u8d44\u672c\u52a0\u5febNMN\u5e02\u573a\u5316\u901f\u5ea6\"<\/figure>\n\n\n\n

    \u76ee\u524d\uff0c\u5728\u56fd\u5185\u7684\u7535\u5546\u5e73\u53f0\u4e0a\u641c\u7d22NMN<\/strong><\/a>\u5173\u952e\u8bcd\uff0c\u666e\u904d\u4ef7\u683c\u504f\u9ad8\uff0c\u8bb8\u591a\u7684\u6d88\u8d39\u8005\u90fd\u5bf9NMN<\/strong><\/a>\u4ea7\u54c1\u8fd8\u5728\u89c2\u671b\u72b6\u6001\u3002NMN<\/strong><\/a>\u5728\u8fc7\u53bb\u51e0\u5e74\u4e2d\u4ec5\u4f5c\u4e3a\u53c2\u4e0e\u76f8\u5173\u7814\u7a76\u7684\u79d1\u5b66\u5bb6\u548c\u6781\u5c11\u6570\u8eab\u4efd\u7279\u6b8a\u7684\u4eba\uff0c\u624d\u6709\u673a\u4f1a\u670d\u7528\u7684\u5962\u4f88\u54c1\u800c\u5b58\u5728\uff0c\u5bf9\u4e8e\u5b9e\u9a8c\u5ba4\u9636\u6bb5\u8d28\u91cf\u9ad8\u7684NMN<\/strong><\/a>\uff0c\u4eba\u5747\u670d\u7528\u6210\u672c\u9ad8\u8fbe\u6bcf\u5e74150\u4e07\u4eba\u6c11\u5e01\u4ee5\u4e0a\u3002\u968f\u7740\u5927\u91cf\u8d44\u672c\u7684\u8fdb\u573a\uff0c\u672a\u6765\u751f\u4ea7\u5de5\u827a\u4f1a\u65e5\u6e10\u6210\u719f\uff0cNMN<\/strong><\/a>\u4ea7\u54c1\u4ef7\u683c\u4e5f\u4f1a\u4e0b\u964d\uff0c NMN<\/strong><\/a>\u5e02\u573a\u4f30\u8ba1\u4f1a\u8fc5\u901f\u6269\u5927\u3002<\/p>\n\n\n\n

    \u6839\u636e\u6d4b\u7b97\uff0c\u5f53\u524d\u56fd\u5185\u6bcf1\uff05\u4fdd\u5065\u54c1\u4eba\u53e3\u5bf9\u5e94\u7684NMN<\/a>\u5e02\u573a\u7a7a\u95f4\u4e3a304\u4ebf\u5143\uff0c\u4f34\u968f\u672a\u6765NMN<\/a>\u6297\u8870\u8001\u4ea7\u54c1\u4e0d\u65ad\u63a8\u5e7f\uff0cNMN<\/strong><\/a>\u884c\u4e1a\u8fdc\u671f\u5e02\u573a\u6709\u671b\u8fbe\u5230\u5343\u4ebf\u89c4\u6a21\u3002<\/strong><\/p>\n\n\n\n

    3. \u7c7b\u4f3c\u201c\u4e0d\u8001\u4ed9\u4e39\u201d\u7684\u529f\u6548\u8fc5\u901f\u63d0\u5347NMN<\/a>\u7684\u5e02\u573a\u77e5\u540d\u5ea6<\/strong><\/h2>\n\n\n\n

    \u957f\u751f\u4e0d\u8001\u81ea\u53e4\u4ee5\u6765\u5c31\u662f\u4eba\u7c7b\u7684\u7ec8\u6781\u68a6\u60f3\uff0c\u5bf9 \u201c\u4e0d\u8001\u4ed9\u4e39\u201d\u7684\u63a2\u5bfb\u4e00\u76f4\u6ca1\u6709\u95f4\u65ad\uff0c\u5e76\u4e14\uff0c\u968f\u7740\u79d1\u5b66\u6280\u672f\u4e0e\u533b\u7597\u624b\u6bb5\u7684\u8fdb\u6b65\uff0c\u8ba9\u4eba\u7c7b\u4f3c\u4e4e\u770b\u5230\u4e86\u4e9b\u8bb8\u7684\u66d9\u5149\u3002\u5404\u56fd\u79d1\u5b66\u5bb6\u7684\u7814\u7a76\u8868\u660e\uff0cNMN<\/strong><\/a>\u7684\u786e\u662f\u53ef\u4ee5\u6539\u5584\u4eba\u4f53\u8870\u8001\u901a\u8def\uff0c\u4ece\u800c\u5b9e\u73b0\u5065\u5eb7\u8870\u8001\uff0c\u8ba9\u9ad8\u9f84\u8001\u4eba\u53ef\u4ee5\u4eab\u53d7\u9ad8\u8d28\u91cf\u7684\u751f\u6d3b\uff0c\u5e2e\u52a9\u4eba\u7c7b\u201c\u5065\u5eb7\u8870\u8001\u201d\u3002NMN<\/strong><\/a>\u867d\u7136\u4e0d\u8ba9\u4ee4\u4eba\u957f\u751f\u4e0d\u8001\uff0c\u4f46\u53ef\u4ee5\u8ba9\u4eba\u5ef6\u7f13\u8870\u8001\u3001\u5b9e\u73b0\u5065\u5eb7\u8870\u8001\u3002\u75ab\u60c5\u4e4b\u540e\uff0c\u5927\u5065\u5eb7\u4ea7\u4e1a\u8fce\u6765\u65b0\u7684\u673a\u9047\uff0c\u4fdd\u5065\u54c1\u884c\u4e1a\u84c4\u52bf\u5f85\u53d1\u3002\u6839\u636e\u534e\u5c14\u8857\u8457\u540d\u6295\u884c\u7f8e\u94f6\u7f8e\u6797\u5206\u6790\uff1a\u81f4\u529b\u4e8e\u5b9e\u73b0\u201c\u62b5\u6297\u8870\u8001\u201d\u7684\u516c\u53f8\uff0c\u5c06\u4f1a\u662f\u672a\u6765\u6295\u8d44\u7684\u4f18\u5148\u9009\u62e9\u3002<\/p>\n\n\n\n

    \"\u786e\u5b9a\u7684\u529f\u6548\u4e5f\u8d77\u5230NMN\u5e02\u573a\u5ba3\u4f20\u7684\u4f5c\u7528\"<\/figure>\n\n\n\n

    <\/p>\n\n\n\n

    AY<\/strong>\u5065\u5eb7<\/strong>NMN27000<\/strong><\/a>\u662f\u63d0\u9ad8\u4eba\u4f53NAD+<\/sup>\u7684\u6c34\u5e73\u3001\u5ef6\u7f13\u8870\u8001\u3001\u63d0\u9ad8\u4eba\u4f53\u7efc\u5408\u514d\u75ab\u529b\u7684\u6838\u5fc3\u81b3\u98df\u8865\u5145\u5242\u3002<\/p>\n\n\n\n

    \"NMN\u5e02\u573a\u7cbe\u54c1\uff1aAy\u5065\u5eb7NMN27000\"<\/figure>\n\n\n\n

    \u9009\u7528\u9ad8\u54c1\u8d28\u7684NMN<\/strong><\/a>\uff0c\u662f\u60a8\u5065\u5eb7\u7684\u4fdd\u8bc1\uff01\u8bf7\u53c2\u89c1: www.nmnsupply.com<\/a>\uff0c\u5168\u65b9\u4f4d\u79d1\u5b66\u4e86\u89e3NMN<\/strong><\/a>\uff01<\/p>\n\n\n\n

      \n
    1. A.P. Gomes, N.L. Price, A.J. Ling, J.J. Moslehi, M.K. Montgomery, L. Rajman, J.P. White, J.S. Teodoro, C.D. Wrann, B.P. Hubbard, E.M. Mercken, C.M. Palmeira, R. de Cabo, A.P. Rolo, N. Turner, E.L. Bell, D.A. Sinclair. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging<\/strong>. Cell<\/em>. 2013<\/strong>, 155(7),1624-38. doi: 10.1016\/j.cell.2013.11.037<\/a>.<\/li>\n\n\n\n
    2. G.M. Uddin, N.A. Youngson, D.A. Sinclair, M.J. Morris. Head to head comparison of short-term treatment with the NAD(+) precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice.<\/strong> Front Pharmacol.<\/em> 2016<\/strong>, 7, 258. doi: 10.3389\/fphar.2016.00258<\/a>.<\/li>\n\n\n\n
    3. G.M. Uddin, N.A. Youngson, B.M. Doyle, D.A. Sinclair, M.J. Morris. Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise<\/strong>. Sci. Rep.<\/em> 2017<\/strong>, 7(1), 15063. doi: 10.1038\/s41598-017-14866-z<\/a>.<\/li>\n\n\n\n
    4. S.J. Mitchell, M. Bernier, M.A. Aon, S. Cortassa, E.Y. Kim, E.F. Fang, H.H. Palacios, A. Ali, I. Navas-Enamorado, A. Di Francesco, T.A. Kaiser, T.B. Waltz, N. Zhang, J.L. Ellis, P.J. Elliott, D.W. Frederick, V.A. Bohr, M.S. Schmidt, C. Brenner, D.A. Sinclair, A.A. Sauve, J.A. Baur, R. de Cabo. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. <\/strong>Cell Metab<\/em>. 2018<\/strong>, 27(3), 667-676.e4. doi: 10.1016\/j.cmet.2018.02.001<\/a><\/li>\n\n\n\n
    5. S. Tarantini, M.N. Valcarcel-Ares, P. Toth, A. Yabluchanskiy, Z. Tucsek, T. Kiss, P. Hertelendy, M. Kinter, P. Ballabh, Z. S\u00fcle, E. Farkas, J.A. Baur, D.A. Sinclair, A. Csiszar, Z. Ungvari.  Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. <\/strong>Redox Biol.<\/em> 2019<\/strong>, 24, 101192. doi: 10.1016\/j.redox.2019.101192<\/a>.<\/li>\n\n\n\n
    6. N.A. Youngson, G.M. Uddin, A. Das, C. Martinez, H.S.Connaughton, S. Whiting, J. Yu, D.A. Sinclair, R.J. Aitken, M.J. Morris.  Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice. <\/strong>Reproduction<\/em>. 2019<\/strong>, 158(2), 169-179. doi: 10.1530\/REP-18-0574<\/a>.<\/li>\n\n\n\n
    7. G.M. Uddin, N.A. Youngson, S.S. Chowdhury, C. Hagan, D.A. Sinclair, M.J. Morris.  Administration of nicotinamide mononucleotide (NMN) reduces metabolic impairment in male mouse offspring from obese mothers. <\/strong>Cells<\/em>. 2020<\/strong>, 9(4), 791. doi: 10.3390\/cells9040791<\/a>.<\/li>\n\n\n\n
    8. X. Chen, J.A. Amorim, G.A. Moustafa, J.J. Lee, Z. Yu, K. Ishihara, Y. Iesato, P. Barbisan, T. Ueta, K.A. Togka, L. Lu, D.A. Sinclair, D.G. Vavvas.  Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. <\/strong>Aging <\/em>(Albany NY). 2020<\/strong>, 12(24), 24504-24521. doi: 10.18632\/aging.202453<\/a>.<\/li>\n<\/ol>\n\n\n\n

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